200 staff. Limitless Potential. One team. Cancer Research Horizons.

Senior Scientist (DMPK)

41,700 – 48,400 plus benefits

Department: Therapeutic Innovation, R&I Reports to: Group Leader Location : Babraham Research Campus, Cambridge (Hybrid minimum 3 days per week on-site) Contract type: 1-year Fixed Term Contract hours: Full time, 35 hours per week

Closing date: Tuesday 21st April 23:55pm Interview Date: Approximately w/c 27th April Interview process: 2 stage interview process, initial screening call via teams followed by on-site competency-based interview.

At Cancer Research UK, we exist to beat cancer.

We have an exciting, high-impact opportunity for a Senior Scientist to join us at Cancer Research Horizons (CRH) in Cambridge, on a 1-year fixed term basis. As a Senior Scientist in DMPK , you will play a key role in advancing both small- and large-molecule programs from lead optimization through candidate selection.

The successful candidate will apply deep technical expertise in pharmacokinetics, metabolism, and quantitative modelling to support the design and execution of translational strategies across therapeutic areas.

Reporting directly to the DMPK Group lead, you will work closely with the medicinal chemistry team and more widely with cross functional teams, seeking to accelerate novel therapies into clinical development.

The role would suit a Senior Scientist with a PhD or BSc/MSc with relevant industrial experience. Good time management skills, a proven ability to form close and effective relationships with colleagues at all levels and excellent written and verbal communication skills are essential. Every role at CRH is united by a single mission: beating cancer sooner. We carry out work that mattersimpacting patients, families, and the future of science.

About Cancer Research Horizons

As the worlds biggest medical research charity, weve helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster.

We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UKs established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUKs world-class academic network, cutting edge technology platforms and clinical expertise to 1) Bring new treatments to patients faster and 2) Tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success.

Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, youll be joining over 200 staff from both industrial and academic backgrounds, all dedicated to bringing forward the day we cure cancer and making real life impact.

What will you be doing?

Develop an appropriate DMPK screening cascade aligned with project stage and objectives.

Design, execute and interpret ADME assays, and communicate results clearly and accurately to project team members.

Oversee CRO activities, including submitting compounds for assays, tracking ongoing experiments, and communicating data updates to the team.

Prepare and regularly update slide decks and other documentation to summarise CRO data and project progress; manage purchase orders and invoicing related to CRO activities.

Maintain accurate, complete and uptodate electronic laboratory notebooks in compliance with internal standards.

Perform LCMS/MS analyses for small and large molecules, including routine maintenance and basic troubleshooting of instruments.

If you have experience in advancing discovery programs from LO through candidate selection that would be desired

Keep abreast of stateoftheart DMPK technologies and developments in cancer therapeutics, and apply new knowledge to ongoing projects where appropriate.

Knowledge of PK-PD /PBPK modelling and human dose prediction would be an asset to the projects

What are we looking for?

Qualified to PhD or BSc/MSc with relevant experience in a life sciences discipline and industrial drug discovery experience.

Practical knowledge of in vitro ADME assays including microsomal stability, hepatocyte stability, protein binding and permeability.

Knowledge and prior experience of using Phoenix WinNonlin.

Knowledge and prior experience of metabolite identification.

Practical experience of bioanalysis by LC-MS/MS is essential (desirable).

Knowledge and prior experience of using MassLynx and UNIFI (desirable).

Good time management skills, a proven ability to form close and effective relationships with colleagues at all levels (both internal and in partner organisations) and excellent written and verbal communication skills.

Our organisation values are designed to guide all that we do.

Bold: Act with ambition, courage and determination

Credible: Act with rigour and professionalism

Human : Act to have a positive impact on people

Together: Act inclusively and collaboratively

Were looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer.

If youre interested in applying and excited about working with us but are unsure if you have the right skills and experience, wed still love to hear from you.

What will I gain?

We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.

You can explore our benefits by visiting our careers web page .

How do I apply?

We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we wont be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively.

For more information on this career opportunity please visit our website or contact us at recruitment@cancer.org.uk .

For more updates on our work and careers, follow us on: Linked In , Facebook , Instagram , X and YouTube .

Our vision is to create a charity where everyone feels like they belong, benefits from and participates in, the work we do. We actively encourage applications from people of all backgrounds and cultures, in particular those from ethnic minority backgrounds who are currently under-represented.

We want to see every candidate performing at their best throughout the job application process, interview process and whilst at work. We therefore ask you to inform us of any concerns you have or any adjustments you might need to enable this to happen. Please contact recruitment@cancer.org.uk or 0 20 3469 8400 as soon as possible.

Unfortunately, we are unable to recruit anyone below the age of 18, so that we can protect young people from health & safety and safeguarding risks.